General Information

  • ID:  hor003991
  • Uniprot ID:  P25271
  • Protein name:  Pseudaletia pheromonotropin
  • Gene name:  NA
  • Organism:  Mythimna separata (Oriental armyworm) (Pseudaletia separata)
  • Family:  Pyrokinin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Mythimna (genus), Hadeninae (subfamily), Noctuidae (family), Noctuoidea (superfamily), Obtectomera, Ditrysia, Heteroneura (parvorder), Neolepidoptera (infraorder), Glossata (suborder), Lepidoptera (order), Amphiesmenoptera (superorder), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity; GO:0005184 neuropeptide hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  KLSYDDKVFENVEFTPRL
  • Length:  18
  • Propeptide:  KLSYDDKVFENVEFTPRL
  • Signal peptide:  NA
  • Modification:  T18 Leucine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Hormone that controls sex pheromone production in larvae.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P25271-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P25271-F1.pdbhor003991_AF2.pdbhor003991_ESM.pdb

Physical Information

Mass: 250387 Formula: C101H154N24O31
Absent amino acids: ACGHIMQW Common amino acids: DEFKLV
pI: 4.54 Basic residues: 3
Polar residues: 4 Hydrophobic residues: 6
Hydrophobicity: -70 Boman Index: -4595
Half-Life: 1.3 hour Half-Life Yeast: 3 min
Half-Life E.Coli: 2 min Aliphatic Index 75.56
Instability Index: 426.11 Extinction Coefficient cystines: 1490
Absorbance 280nm: 87.65

Literature

  • PubMed ID:  1734867
  • Title:  Isolation and Primary Structure of a Novel Pheromonotropic Neuropeptide Structurally Related to Leucopyrokinin From the Armyworm Larvae, Pseudaletia Separata